Nebulized Heparin in Adults With Acute Respiratory Failure: A Meta-Analysis of Randomized Trials - PubMed
6 hours ago
- #meta-analysis
- #respiratory failure
- #nebulized heparin
- Meta-analysis of 16 randomized trials (787 heparin, 833 control) on nebulized heparin in adults with acute respiratory failure.
- Primary outcome: nebulized heparin reduced all-cause mortality at longest follow-up (RR 0.79; 95% CI, 0.66-0.95).
- Secondary benefit: increased ventilation-free days by day 28 (mean difference +4.85 days).
- Safety: major bleeding rare (1.1% vs. 0.7%), no reported minor bleeding or heparin-induced thrombocytopenia.
- Conclusion: Nebulized unfractionated heparin may improve survival without increasing adverse events.