Quercetin prevents age-related hearing loss in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome - PubMed
2 days ago
- #mitophagy
- #age-related hearing loss
- #quercetin
- Quercetin prevents age-related hearing loss (ARHL) in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome.
- ARHL is linked to NLRP3 inflammasome activation and mitochondrial dysfunction.
- Quercetin, a natural flavonoid, has anti-inflammatory and antioxidant properties.
- The study administered quercetin to mice from 6 to 12 months and evaluated hearing function via ABR and cochlear tissue morphology via HE staining.
- Quercetin reduced ABR threshold shifts and improved cochlear tissue morphology.
- It decreased oxidative stress and inflammatory factors (TNF-α, IL-6, IL-18, IL-1β) in the cochlea and auditory cortex.
- Quercetin attenuated NLRP3 inflammasome activation, reducing NLRP3, ASC, IL-1β, IL-18, caspase-1, and cleaved caspase-1 expression.
- It promoted mitophagy-related gene expression (PINK1, PARKIN, BNIP3, LC3B) and increased the LC3B-II/LC3B-I ratio.
- The findings suggest quercetin protects against ARHL by modulating mitophagy and suppressing NLRP3 inflammasome activation.