GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis - PubMed
6 hours ago
- #glaucoma
- #retinal ganglion cells
- #ferroptosis
- GHRHR deficiency enhances retinal ganglion cell (RGC) survival and visual functions in experimental glaucoma by inhibiting ferroptosis.
- GHRHR deficiency prevents downregulation of anti-ferroptotic mediators GPX4 and FTH1 and suppresses pro-ferroptotic factor ACSL4.
- GHRHR inhibition reduces iron accumulation, lipid peroxidation, and reactive oxygen species (ROS) accumulation in RGCs.
- Single-cell transcriptomic analysis reveals RGC-specific alterations in genes related to ferroptosis, lipid metabolism, oxidative stress, and mitochondrial dynamics.
- Pharmacological GHRHR inhibition in mitochondria-damaged primary RGCs reduces lipid peroxidation and mitochondrial ROS, improving RGC survival.
- GHRHR inhibition is identified as a potential therapeutic strategy for glaucomatous neurodegeneration, preserving both structural and functional retinal integrity.