Context-dependent translation inhibition as a cancer therapeutic modality - PubMed
5 hours ago
- #ribosome
- #translation inhibition
- #cancer therapy
- Context-dependent translation inhibition is explored as a cancer therapeutic strategy.
- Small molecules, termed interdictors, are designed to bind the human ribosome's peptidyl transferase center (PTC) and inhibit translation in a context-dependent manner.
- Interdictors interact preferentially with nascent protein residues, causing structural changes in the polypeptide chain and ribosomal RNA.
- These compounds differentially affect ribosome surveillance pathways, including the ribotoxic stress response.
- Anti-tumor activity of interdictors is confirmed in a mouse xenograft model of triple-negative breast cancer.
- The study suggests context-dependent translation inhibition as a potential therapeutic approach for difficult-to-treat cancers.