Novel optimization of multi-mechanistic approaches for the acute treatment of a migraine attack: A review - PubMed
3 days ago
- #acute-treatment
- #combination-therapy
- #migraine
- Migraine involves peripheral and central sensitization processes.
- Current monotherapies do not effectively target both migraine processes.
- Combination therapies like aspirin/acetaminophen/caffeine and sumatriptan/naproxen sodium show superiority over monotherapies.
- Sumatriptan/naproxen sodium is the most effective combination, targeting early and late migraine stages.
- Optimizing pharmacokinetic profiles of combination therapies could enhance effectiveness.
- Further research is needed to develop more effective multi-mechanistic treatments.