Frazzled/DCC directs spatial progenitor integration ensuring steady-state intestinal turnover - PubMed
5 hours ago
- #Drosophila midgut
- #intestinal homeostasis
- #progenitor migration
- Frazzled/DCC directs spatial progenitor integration in the Drosophila midgut for steady-state turnover.
- Netrin-B ligands from worn-out enterocytes attract Frazzled/DCC-receptor dependent EB protrusions.
- EB migration towards Netrin-B sources ensures replacement of both adjacent and remote enterocytes.
- The 'Hamelin' assay confirms Frazzled-dependent EB migration and hints at invasive progenitor behavior.
- Netrins and Frazzled/DCC-signaling are potential therapeutic targets in metastasis.