A NIR-Ⅱ Fluorescent Probe for Real-Time Visualization and Early Assessment of Responses to CDK4/6 Inhibitors in Breast Cancer - PubMed
5 hours ago
- #NIR-II imaging
- #breast cancer
- #CDK4/6 inhibitors
- Development of a NIR-II fluorescent probe (HSA-ICi) for real-time visualization of CDK4/6 inhibitor responses in breast cancer.
- HSA-ICi targets the CDK4/6-cyclin D complex, shows high tumor accumulation, and enables early pharmacodynamic response monitoring.
- Significant decrease in tumor fluorescence signal detected one week post-treatment, preceding changes in tumor volume.
- Early signal reduction correlates with decreased pRB and Ki-67 expression in tumor tissues.
- Probe distinguishes between CDK4/6 inhibitor-sensitive and -resistant tumors, aiding in early resistance identification.
- Potential to facilitate timely treatment adaptation for HR+/HER2- breast cancer patients.