Gut microbiota-liver-kidney axis in diabetic kidney disease: mechanistic insights into amino acid metabolism and nutritional intervention strategies targeting natural bioactive compounds - PubMed
3 hours ago
- #gut microbiota axis
- #nutritional intervention
- #diabetic kidney disease
- The gut microbiota-liver-kidney axis is crucial in diabetic kidney disease (DKD), linking diet to pathogenesis.
- Gut microbiota metabolizes dietary components: fiber produces protective short-chain fatty acids (SCFAs), while aromatic amino acids generate harmful uremic toxins.
- DKD involves intestinal barrier dysfunction and metabolic endotoxemia, perpetuating inflammation and kidney injury.
- Nutritional interventions like Mediterranean diet, plant proteins, and prebiotics can modulate microbiota, boost SCFAs, and reduce toxins.
- Natural bioactive compounds (e.g., berberine, quercetin) and 'medicine food homology' substances offer renoprotective effects by restoring microbiota and barrier integrity.
- Future strategies include precision nutrition using multi-omics and AI for personalized dietary plans based on individual microbiota profiles.