TWIST1-Mediated Induction of AEBP1 in Fibroblast-like Synoviocytes Activates TGF-β Signaling to Drive Angiogenesis and Promote Rheumatoid Arthritis - PubMed
3 days ago
- #Fibroblast-like Synoviocytes
- #TWIST1-AEBP1-POSTN axis
- #Rheumatoid Arthritis
- TWIST1-mediated induction of AEBP1 in fibroblast-like synoviocytes (FLS) activates TGF-β signaling, driving angiogenesis and promoting rheumatoid arthritis (RA).
- A pathogenic POSTN+ FLS subgroup was identified in the synovial sublining, exhibiting ECM remodeling and fibrogenic features.
- AEBP1 activates TGF-β signaling in FLS, promoting fibroblast activation, migration, and proliferation, and induces POSTN expression for neovascularization.
- Inflammatory signals induce TWIST1, which directly regulates AEBP1 transcription in FLS.
- Pharmacological inhibition of TWIST1 by harmine reduces AEBP1 and POSTN expression, limits pathogenic THY1+ FLS expansion, and alleviates joint pathology in CIA mice.
- Targeting the TWIST1-AEBP1-POSTN axis may offer a novel therapeutic approach for RA treatment.