DRP1 induces neuroinflammation via transcriptional regulation of NF-ĸB - PubMed
6 hours ago
- #DRP1
- #neuroinflammation
- #NF-kappaB
- DRP1, known for mitochondrial fission, also acts as a transcription factor regulating neuroinflammation.
- Upon LPS stimulation, DRP1 moves to the nucleus and binds to the Rela promoter, activating NF-κB and inflammatory cytokines.
- The study highlights the role of lipocalin-2 in brain inflammation and identifies DRP1-mediated pathways as potential therapeutic targets for neurodegenerative diseases.