Multi-target protective effects of Agrimonia pilosa Ledeb. against metabolic dysfunction-associated steatohepatitis in mice - PubMed
3 days ago
- #metabolic-disorders
- #herbal-medicine
- #liver-health
- Agrimonia pilosa Ledeb. (AP) is a traditional herbal medicine rich in flavonoids, phenolics, triterpenoids, and glycosides.
- AP demonstrated significant therapeutic effects in a MASH mouse model by reducing body weight, liver index, and serum markers (AST, ALT, TG, TC, LDL-c).
- In vitro, AP suppressed lipogenesis (downregulated SREBP-1c, FASN, SCD1) and promoted fatty acid β-oxidation (upregulated CPT1A) in AML12 hepatocytes.
- AP inhibited LPS-induced inflammatory cytokines (TNF-α, IL-1β, IL-6) in RAW264.7 macrophages.
- 83 active constituents and 25 key targets were identified, with HMGCR and AXL as hub nodes.
- Agrimol B (AGB) showed strong binding affinity to HMGCR and AXL, inhibiting HMGCR and enhancing LXRα/β-mediated cholesterol efflux.
- AP ameliorates MASH through coordinated regulation of lipid metabolism, inflammation suppression, and collagen deposition.