Adverse outcome pathway analysis identifies DRP1-driven mitochondrial dysfunction as a central event in silver nanoparticle-induced hepatocyte ferroptosis - PubMed
7 hours ago
- #mitochondrial dysfunction
- #nanotoxicology
- #ferroptosis
- Silver nanoparticles (AgNPs) raise biosafety concerns due to their widespread use.
- The liver is a primary target organ for AgNP exposure.
- Adverse outcome pathway (AOP) analysis identifies mitochondrial dysfunction as a key event in AgNP-induced hepatotoxicity.
- DRP1-driven mitochondrial fission and increased mitochondrial reactive oxygen species (mtROS) are central to the toxicity mechanism.
- DRP1 phosphorylation at Ser616 activates p62/PINK1-dependent mitophagy, mitigating oxidative damage.
- The study highlights the AOP framework's utility in nanoparticle risk assessment and regulatory decisions.