Role of myeloid cells expressing CD169/Siglec-1 in host - pathogen interactions - PubMed
7 hours ago
- #pathogens
- #CD169
- #immune response
- CD169/Siglec-1 is a lectin receptor expressed on macrophages and monocytes, crucial for immune surveillance and adaptive immunity.
- It recognizes sialylated structures on viruses like HIV-1, SARS-CoV-2, and Ebola, as well as bacterial capsules.
- CD169+ cells can enhance immune responses but also facilitate pathogen dissemination, notably in HIV-1 trans-infection.
- CD169 expression is induced by type-I interferons during viral infections, serving as a biomarker for viral vs. bacterial infections.
- Its dual role in protection and pathogen exploitation necessitates careful therapeutic strategy development.