Estrogen deficiency and risk of hearing loss in pediatric Turner syndrome - PubMed
4 hours ago
- #Hearing loss
- #Turner syndrome
- #Estrogen replacement therapy
- Estrogen deficiency in pediatric Turner syndrome (TS) increases the risk of hearing loss (HL).
- The study found that estrogen-deficient TS patients had a higher incidence of HL (56.3%) compared to estrogen-normal patients (28.2%).
- Estrogen deficiency independently increased HL risk (HR = 2.93) and predicted abnormal DPOAE (HR = 3.98).
- Early initiation of estrogen replacement therapy (ERT) around age 12 significantly preserved auditory function and slowed hearing deterioration.
- The study suggests childhood estrogen deficiency is a modifiable risk factor for HL in TS patients.