BST-2 inhibits SARS-CoV-2 egress at intracellular membranes and is neutralized by ORF7a - PubMed
4 hours ago
- #BST-2
- #SARS-CoV-2
- #Viral Restriction
- BST-2 inhibits SARS-CoV-2 virus-like particle (VLP) release in HEK293T and Calu-3 cells.
- BST-2 colocalizes with SARS-CoV-2 structural proteins at the ERGIC, restricting viral egress.
- SARS-CoV-2 ORF7a counteracts BST-2 by promoting its degradation and restoring VLP release.
- ORF3a promotes VLP release independently of BST-2, without affecting its expression or localization.
- ORF7a also relieves BST-2-mediated restriction on HIV-1 VLP release, indicating a conserved antagonistic function.