Multi omics analysis reveals senescence associated genes in metabolic dysfunction associated steatohepatitis related liver cancer and their functional validation - PubMed
6 hours ago
- #Liver cancer
- #Senescence-associated genes
- #Multi-omics
- MRLC (Metabolic Dysfunction Associated Steatohepatitis Related Liver Cancer) is a senescence-associated disease primarily affecting the elderly globally.
- Four senescence-associated genes (SAGs)—SOD2, ALDH2, MME, and IGFBP1—are differentially expressed in MRLC and may promote cancer progression by metabolic reprogramming and reshaping the immune microenvironment.
- The study identifies EPZ5676 as a potential therapeutic drug for MRLC, showing high affinity for all four SAGs through molecular docking.