Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation - PubMed
a day ago
- #monocyte-derived cells
- #arginine metabolism
- #neuroinflammation
- Monocyte-derived cell (Mdc) infiltration into the central nervous system (CNS) during neuroinflammation leads to significant metabolic changes, notably increased arginine catabolism driven by arginase 1 (Arg1)-expressing Mdcs.
- This enhanced arginine breakdown promotes oxidative damage, lipid accumulation, and Mdc dysfunction, exacerbating neuroinflammatory conditions.
- Genetic deficiency of ARG1 in Mdcs increases extracellular arginine, rewires CNS metabolism to reduce disease-linked metabolites, and promotes anti-inflammatory responses and regulatory T cell expansion, improving disease outcomes.
- Dietary arginine deficiency reverses these benefits, highlighting the pleiotropic positive role of arginine in mitigating neuroinflammation.