Distinct macular structural and microvascular alterations differentiate neuromyelitis optica spectrum disorder from myelin oligodendrocyte glycoprotein antibody-associated disease in optic neuritis -
5 hours ago
- #neuromyelitis optica spectrum disorder
- #optic neuritis
- #retinal biomarkers
- Both NMOSD and MOGAD cause macular structural and microvascular damage in optic neuritis, associated with reduced best-corrected visual acuity.
- NMOSD-ON eyes show greater reduction in choriocapillaris blood flow area compared to MOG-ON eyes, aiding differentiation.
- Microvascular density, vascular density, blood flow area, and GCIPL thickness are reduced in affected eyes of both conditions versus healthy controls.
- In NMOSD-ON eyes, all microvascular parameters inversely correlate with visual acuity and disability scores.
- In MOG-ON eyes, specific parameters correlate inversely with visual acuity and disease duration.
- Unaffected eyes in MOGAD also show reduced microvascular parameters compared to healthy controls, but less severe than affected eyes.