Sphingomonas paucimobilis-Driven Epithelial-Endothelial Transition in Adenomyosis Pathogenesis - PubMed
4 hours ago
- #adenomyosis
- #epithelial-endothelial transition
- #Sphingomonas paucimobilis
- Identified epithelial-endothelial transition (EET) as a key mechanism in adenomyosis pathogenesis.
- Discovered transitional cells co-expressing epithelial (EPCAM) and endothelial (PECAM1) markers.
- Found significant enrichment of Sphingomonas paucimobilis in adenomyosis lesions, co-localized with EET cells.
- Mouse experiments confirmed live S. paucimobilis inoculation recapitulates adenomyosis development.
- Validated TNFα → NF-κB → MMP signaling cascade as critical for EET and adenomyosis progression.
- Protein-level changes confirmed across human tissue, mouse models, and cell cultures.
- Study identifies novel microbial-driven cellular transformation and potential therapeutic targets.