Multi-omics biomarkers in female fertility: from oocyte quality to endometrial receptivity and clinical translation - PubMed
6 hours ago
- #female fertility
- #multi-omics biomarkers
- #clinical translation
- High-throughput omics technologies have advanced understanding of female reproductive biology, including oocyte maturation, ovarian reserve, endometrial receptivity, and embryo development.
- Multi-omics biomarkers are explored across three clinically accessible compartments: the follicular unit, the endometrium, and the embryo.
- Transcriptomic markers, metabolic profiles, immune and decidualization programs, and embryo secretomic footprints are key single-layer signatures.
- Integrative analytical frameworks and computational modeling improve prediction accuracy and reveal coordination failures not visible with single-omics approaches.
- Multi-omics approaches help distinguish timing misalignment from intrinsic endometrial dysfunction and improve embryo selection.
- Translational challenges include workflow constraints, lack of standardization, limited external validation, and cost-effectiveness issues.
- Future directions include precision-guided treatment strategies, proactive fertility monitoring, and AI-driven decision support.