Dysferlin stabilizes membrane nanodomains of cardiomyocytes after myocardial infarction - PubMed
6 hours ago
- #Dysferlin
- #Cardiomyocytes
- #Myocardial Infarction
- Dysferlin upregulation is crucial for stabilizing sarcolemmal nanodomains in cardiomyocytes after myocardial infarction.
- Dysferlin knockout mice exhibit larger infarct sizes and reduced left-ventricular function post-MI compared to wild-type mice.
- Spatial proteomics and microscopy reveal dysferlin's role in preserving transverse-axial tubule networks and intercalated disc structures in the MI border zone.
- Dysferlin interacts with proteins at nanodomains, indicating its importance in maintaining membrane integrity and limiting post-MI contractility loss.