Cell-type specificity of Tim-3 in respiratory diseases: from mechanisms to clinical translation - PubMed
6 hours ago
- #immunotherapy
- #immune checkpoint
- #respiratory diseases
- Tim-3 is an immune checkpoint molecule expressed on T cells and other immune cells, playing a key role in immune homeostasis and inflammation control.
- The article reviews Tim-3's expression changes, mechanisms, and clinical relevance in respiratory diseases like asthma, COPD, ARDS, lung infections, lung cancer, and pulmonary fibrosis.
- Tim-3 has a dual role in respiratory diseases, being both protective and pathogenic.
- The potential of Tim-3 as a disease biomarker and a new target for immunotherapy is discussed.
- Keywords include T cell exhaustion, TIM-3, immune checkpoint, immune regulation, and respiratory diseases.