Picalm Coordinates Clathrin-Mediated Endocytosis And Actin Remodeling During Myogenesis - PubMed
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- #Picalm
- #endocytosis
- Picalm is identified as a novel regulator of myogenesis, coordinating clathrin-mediated endocytosis and actin remodeling.
- Picalm depletion in C2C12 myoblasts impairs differentiation due to disrupted intracellular trafficking of cell surface proteins.
- Inhibition of dynamin-dependent endocytosis worsens myogenesis in Picalm-depleted cells, highlighting Picalm's role in endocytic function.
- Picalm knockdown reduces clathrin-dependent EGF uptake and alters the plasma membrane proteome, affecting vesicular trafficking and actin remodeling.
- Pharmacological stabilization of actin filaments with Jasplakinolide rescues myogenic differentiation in Picalm-deficient cells.
- Picalm expression is responsive to metabolic cues like exercise and intermittent fasting, linking nutrient signaling to myogenesis.