Identification and validation of an 11-kinase signature that predicts chemo- and radiosensitivity in gastric cancer - PubMed
8 days ago
- #biomarker
- #machine-learning
- #gastric-cancer
- Identified an 11-kinase signature predicting chemo- and radiosensitivity in gastric cancer (GC).
- Stratified 893 GC patients into EMT and metabolism subgroups with distinct treatment responses.
- Metabolism subgroup showed better survival with chemotherapy (HR=0.56) and radiotherapy (HR=0.55).
- No survival improvement observed in the EMT subgroup with these treatments.
- The kinomic taxonomy was distinct from Lauren classification and transcriptomic subtypes.
- Model developed using machine learning and validated with multiple datasets.
- Potential to optimize chemotherapy and radiotherapy decisions for GC patients.