A ESRP1/circPHGDH/miR-149/RAP1B positive feedback loop promotes the malignant behaviors and glycolysis of prostate cancer cell - PubMed
5 hours ago
- #glycolysis
- #circular RNA
- #prostate cancer
- Circular RNA circPHGDH is upregulated in prostate cancer (PCa) tissues and cells.
- Knockdown of circPHGDH inhibits PCa cell proliferation, migration, invasion, epithelial-mesenchymal transition, and glycolysis.
- circPHGDH acts as a sponge for miR-149, which directly targets RAP1B.
- The splicing factor ESRP1 regulates the biogenesis of circPHGDH.
- Glycolytic product lactate stabilizes ESRP1 via lactylation at the K43 site.
- circPHGDH knockdown suppresses ESRP1 lactylation and inhibits tumor growth and metastasis in vivo.
- The ESRP1/circPHGDH/miR-149/RAP1B axis drives PCa progression, offering potential therapeutic targets.