Outcomes of Density-Targeted Supplemental Breast Magnetic Resonance Imaging Screening by Breast Cancer Risk: Long-Term Health and Economic Considerations - PubMed
6 hours ago
- #MRI cost-effectiveness
- #health economics
- #breast cancer screening
- Study evaluates supplemental breast MRI strategies for women with varying breast cancer risks.
- Simulation includes women aged 40+ undergoing digital breast tomosynthesis (DBT) with or without MRI.
- DBT alone averts 7.4-10.5 breast cancer deaths per 1000 average-risk women.
- DBT with supplemental MRI (DBT+MRId) averts 0.1-0.8 additional deaths but increases false-positive biopsies.
- Biennial DBT+MRId starting at 50 is more effective but less cost-effective than DBT starting at 45.
- Cost-effectiveness sensitive to cancer risk, MRI costs, and false-positive biopsy rates.
- Supplemental MRI recommended for women with dense breasts and higher-than-average risk (RR ≥2.0).
- Study funded by the National Cancer Institute.