Novel hypertension phenotypes based on cross-classification of 24-h brachial and aortic SBP - PubMed
5 hours ago
- #Ambulatory Blood Pressure Monitoring
- #Hypertension Phenotypes
- #Left Ventricular Hypertrophy
- The study introduces novel hypertension phenotypes by cross-classifying 24-hour brachial and aortic systolic blood pressure (brSBP/aoSBP).
- Four phenotypes were defined: Concordant Systolic Normotension (CSN), Isolated Brachial Systolic Hypertension (IbrSH), Isolated Aortic Systolic Hypertension (IaoSH), and Concordant Systolic Hypertension (CSH).
- In a cohort of 8,738 participants, IaoSH had a prevalence of 7.7%, showing a U-shaped age distribution in men and linear in women, and was linked to lower heart rate and beta-blocker use.
- IbrSH had a prevalence of 6.5%, exhibiting an inverted U-shaped age distribution, and was associated with higher heart rate and calcium channel blocker use.
- Only IaoSH, not IbrSH, was significantly associated with left ventricular hypertrophy (LVH), showing 2.6 times higher odds compared to CSN after adjustment for covariates.
- Both IaoSH and IbrSH together accounted for nearly 15% of cases, highlighting distinct clinical characteristics and the need for outcome-driven trials to assess their relevance.