Genomic structural variations contribute to inform prognosis in patients with cytogenetically normal acute myeloid leukemia - PubMed
4 days ago
- #acute myeloid leukemia
- #genomic structural variations
- #prognosis
- Genomic structural variations (SVs) help predict prognosis in cytogenetically normal acute myeloid leukemia (CN-AML) patients.
- A study identified 5 somatic SVs linked to shorter overall survival (OS) and event-free survival (EFS) in 13% of CN-AML patients.
- High-risk SVs (HRVs) define a 'very high-risk' category within ELN2022, improving OS prediction accuracy.
- HRVs are independent of common mutations like FLT3ITD and NPM1mut, and predict worse outcomes even in these subgroups.
- Transcriptional deregulation of SV-related genes was observed in primary samples and cell models.
- Findings support using SVs for better risk stratification in CN-AML to guide personalized treatment approaches.