The risk for the development of hypertensive complications in oocyte donation pregnancy: a systematic review and individual participant data meta-analysis (DONOR IPD) - PubMed
6 hours ago
- #oocyte donation
- #hypertensive disorders
- #preeclampsia
- Oocyte donation (OD) pregnancies have a significantly higher risk of hypertensive complications compared to autologous pregnancies (both naturally conceived and IVF/ICSI), with adjusted odds ratios of 2.62-2.85 for overall hypertensive disorders.
- The risk is particularly pronounced for preeclampsia (PE), showing high certainty evidence with adjusted odds ratios of 2.28-2.39, while pregnancy-induced hypertension (PIH) results are less consistent (low certainty).
- Subgroup analyses indicate that increased risks for hypertensive complications in OD pregnancies persist regardless of maternal age, BMI, parity, ethnicity, medical history, or multiple pregnancy status.
- The use of preventive treatments like acetylsalicylic acid or heparin during OD pregnancy may lower the risk of hypertensive complications, though more evidence is needed to confirm this effect and understand the underlying mechanisms.
- This individual participant data (IPD) meta-analysis enhances reliability by correcting for confounders and reducing bias, offering the best evidence to date to inform international obstetric guidelines and increase healthcare provider alertness.