Chronic Spontaneous Urticaria Combined Atopic Dermatitis/Other Atopic Comorbidities: Clinical Characteristics, Therapeutic Response to Omalizumab, and Drug Survival - PubMed
4 hours ago
- #omalizumab
- #chronic spontaneous urticaria
- #atopic comorbidities
- The study compares chronic spontaneous urticaria (CSU) patients with atopic dermatitis (AD), other atopic comorbidities (OACs), and no atopic comorbidities.
- CSU-OAC patients had earlier disease onset, higher angioedema prevalence, faster response to omalizumab, higher drug survival, but more adverse events.
- CSU-AD patients showed higher baseline disease activity but similar treatment response and drug survival to CSU-NA patients.
- Adverse events, especially injection-site reactions and systemic effects, were significantly higher in CSU-OAC patients.
- The findings suggest CSU-OAC requires individualized management due to distinct clinical features and treatment outcomes.