Integration of triglyceride-glucose index and biological aging to predict cardiovascular disease risk in cardiovascular-kidney-metabolic syndrome stages 0-3: a multiple prospective cohort study - PubM
5 hours ago
- #Biological aging
- #Cardiovascular disease
- #Insulin resistance
- The study integrated triglyceride-glucose (TyG) index and biological aging (KDM-BA) to predict cardiovascular disease (CVD) risk in individuals with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3.
- Using multiple cohorts including UK Biobank and CHARLS, the combined TyG-KDM-BA index was associated with significantly higher CVD risk, with hazard ratios up to 3.97 for the highest quartile.
- TyG-KDM-BA demonstrated superior predictive performance over traditional TyG-derived indicators, with improved discrimination and incremental value in risk prediction models.
- The findings suggest TyG-KDM-BA could serve as an effective tool for early screening and intervention in CKM syndrome populations.