Brain neuronal CG9593/ANGPTL4 activation mediates paternally acquired motor disorders - PubMed
5 hours ago
- #epigenetics
- #heavy metal stress
- #motor disorders
- Paternal environmental heavy metal stress leads to multigenerational motor deficits in offspring.
- CG9593/ANGPTL4 identified as a key brain effector linking paternal stress to motor disorders.
- Neuron-specific CG9593 knockdown improves motor disorders, while overexpression mimics them.
- m6A hypermethylation in sperm stabilizes CG9593 mRNA in offspring neurons via IGF2BP1.
- Serum ANGPTL4 levels negatively correlate with pediatric motor scores in humans.
- Paternal sperm m6A levels are positively associated with heavy metal exposure burden.