The temporal sequence of myasthenia gravis and neuromyelitis optica spectrum disorder: a case report and systematic review of 74 patients - PubMed
5 hours ago
- #eculizumab
- #myasthenia gravis
- #neuromyelitis optica spectrum disorder
- The co-occurrence of myasthenia gravis (MG) and neuromyelitis optica spectrum disorder (NMOSD) is rare.
- A case report of a 43-year-old woman with pre-existing MG who developed NMOSD is presented.
- A systematic review identified 74 patients with both MG and NMOSD.
- There is a marked female predominance (89.2%) in the cohort.
- MG onset significantly preceded NMOSD onset in most patients (93.2%).
- The mean age at onset was younger for MG (28.19 years) compared to NMOSD (41.02 years).
- The mean interval between MG and NMOSD onset was 12.56 years.
- AChR-Ab was positive in 90.5% and AQP4-Ab in 73.0% of tested patients.
- Eculizumab (a complement C5 inhibitor) showed marked clinical improvement in the case report.
- The study suggests a shared autoimmune predisposition and highlights complement pathway inhibition as a potential therapeutic strategy.