Systematic characterization of pyroptosis-related gene patterns identifies potential prognostic inflammatory phenotypes in sepsis - PubMed
4 hours ago
- #Immune Infiltration
- #Pyroptosis
- #Sepsis Prognosis
- Identified two distinct pyroptosis-related gene (PRG) patterns in sepsis with one subtype associated with poorer prognosis and enriched inflammatory pathways.
- Constructed a 7-gene PRG-score (TUBG2, TNFAIP3, CXCL8, WFDC1, DEFA4, CX3CR1, ZBP1) predictive of short-term mortality in sepsis, validated in independent cohorts.
- Higher PRG-scores linked to immune remodeling features like increased M0/M2 macrophages, reduced CD8+ T cells, and elevated immune checkpoint expression.