TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function - PubMed
7 days ago
- #γδ T cells
- #antigen sensitivity
- #TCRγ constant domains
- TCRγ constant domains modulate activation intensity in human γδ T cells, independent of variable region antigen recognition.
- Cγ1 usage is associated with a more differentiated cytotoxic effector phenotype in the thymus and higher granzyme expression in peripheral tissues.
- TCRs with Cγ1 are selectively expanded in colorectal tumors.
- Cγ2 usage correlates with naïve phenotypes during development and with inhibition and wound healing in the periphery.
- The modulation of activation via Cγ1 or Cγ2 influences γδ T cell phenotype and clonal expansion throughout its lifespan.