Identifying druggable proteins of the association of chronotype on breast cancer using Mendelian randomization - PubMed
5 hours ago
- #chronotype
- #Mendelian randomization
- #breast cancer
- Morning chronotype is associated with a reduced risk of breast cancer (odds ratio 0.93, 95% CI 0.89-0.98).
- A two-step Mendelian randomization analysis identified 895 plasma proteins associated with morning chronotype.
- Seven proteins showed inverse associations with overall breast cancer, with five confirmed as mediators through colocalization.
- The five key mediator proteins are ADAM15, BTN2A1, CASP8, PDCD6, and RSPO3.
- Single-cell RNA sequencing in breast cancer tissues supports the biological relevance of these proteins.
- These findings provide mechanistic insights linking chronotype to breast cancer and suggest potential therapeutic targets.