Semaglutide attenuates diabetic vascular calcification by enhancing autophagy and lysosomal function via targeting CPNE1 - PubMed
5 days ago
- #Diabetic vascular calcification
- #Semaglutide
- #Autophagy
- Semaglutide reduces diabetic vascular calcification in a dose-dependent manner.
- It downregulates RUNX2 and BMP2 protein expression in aortic tissues.
- Semaglutide restores autophagic flux and lysosomal function impaired by AGEs-BSA.
- The drug significantly downregulates CPNE1, a calcium-dependent phospholipid-binding protein.
- Findings suggest Semaglutide's potential as a novel therapeutic for diabetic vascular calcification.