BACH2 ameliorates cell apoptosis and autophagy as a molecular switch of BCL-2/Beclin-1 complex in myocardial infarction - PubMed
6 hours ago
- #BACH2
- #Myocardial Infarction
- #Apoptosis
- BACH2 plays a crucial role in ameliorating cell apoptosis and autophagy in myocardial infarction.
- BACH2 acts as a molecular switch by promoting BCL2 expression and forming the BCL2/Beclin-1 complex.
- Cardiac-specific knockout of BACH2 worsens, while knockin improves cardiac dysfunction in myocardial infarction models.
- BACH2 translocates from the nucleus to the cytoplasm under hypoxia/reoxygenation (H/R) stimulation.
- The natural compound Myricetin was identified as an effective BACH2 activator, offering therapeutic potential.
- Targeting BACH2 with small molecules could be a promising strategy for treating myocardial infarction.