The regulation of mitochondrial ferritin on mitochondrial redox balance is essential to cell fate decision - PubMed
6 hours ago
- #Cell fate
- #Redox balance
- #Mitochondrial ferritin
- Mitochondrial ferritin (FtMt) is an iron-storage protein with high homology to cytoplasmic ferritin but has distinct properties.
- FtMt plays a crucial role in mitochondrial redox balance by isolating iron, reducing oxidative stress, and maintaining mitochondrial homeostasis.
- It modulates the labile iron pool in mitochondria, aiding in iron-sulfur cluster biosynthesis and supporting cellular respiration.
- FtMt influences cell fate decisions, including apoptosis and ferroptosis, by altering mitochondrial integrity.
- Dysregulation of FtMt is linked to neurodegenerative diseases, cardiovascular disorders, and cerebrovascular pathologies.
- Targeting FtMt and mitochondrial redox homeostasis presents potential therapeutic strategies for these diseases.