Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis - PubMed
4 hours ago
- #Inflammatory Bowel Disease
- #Colorectal Cancer
- #Caspase-3/7
- Caspase-3/7 deficiency in intestinal epithelial cells (IECs) worsens colitis, increases mortality, and impairs tissue regeneration.
- Deficiency in caspase-3/7 disrupts stem cell proliferation and increases inflammatory cell death, leading to compromised barrier integrity and delayed recovery.
- Despite heightened inflammation, Casp3/7-deficient mice show reduced tumor formation in colorectal cancer models.
- The study suggests caspase-3/7 plays a protective role in inflammation control and tissue regeneration but promotes tumorigenesis after intestinal injury.
- Modulation of caspase-3/7 could be a therapeutic strategy for inflammatory bowel disease (IBD) and colorectal cancer.