We now know why some people had blood clots after Covid shots
4 days ago
- #blood clots
- #COVID-19 vaccines
- #adenovirus vectors
- Rare blood clots (VITT) reported in recipients of AstraZeneca and Johnson & Johnson COVID-19 vaccines.
- VITT linked to antibodies against platelet factor 4 (PF4), causing abnormal clotting and low platelet counts.
- Adenovirus-based vaccines (AstraZeneca, J&J) triggered immune responses due to similarities between viral protein VII and PF4.
- Patients with VITT shared specific antibody gene variants (IGLV3-21*02 or *03) and a critical mutation enhancing PF4 binding.
- Study identifies protein VII as the trigger, offering insights for safer adenoviral vector vaccine designs.