Memory loss is fuelled by gut microbes in ageing mice
2 days ago
- #gut-brain axis
- #cognitive decline
- #aging research
- A study found that a gut bacteria species, Parabacteroides goldsteinii, proliferates in aging mice and contributes to cognitive decline.
- The bacteria interfere with sensory nerve signaling to the brain, a mechanism possibly conserved in humans.
- Young mice co-housed with old mice showed similar memory deficits, linked to microbiome changes.
- Transplanting P. goldsteinii into young mice worsened their memory, while antibiotics or phage therapy improved memory in old mice.
- The findings suggest gut-targeted therapies could potentially reverse age-related cognitive decline.