SEL1L-HRD1 ERAD-autophagy interplay maintains mitochondrial homeostasis in brown adipocytes - PubMed
7 hours ago
- #mitochondrial homeostasis
- #ERAD-autophagy crosstalk
- #brown adipocytes
- The SEL1L-HRD1 ERAD pathway and autophagy work together to maintain mitochondrial integrity in brown adipocytes.
- Simultaneous deletion of Sel1L and Atg7 (DKO) in mice causes significant mitochondrial abnormalities, unlike single deletions.
- DKO adipocytes show hyperfused megamitochondria with excessive ER-mitochondrial contacts and impaired thermogenesis.
- The study reveals a mitochondrial surveillance mechanism based on ERAD-autophagy crosstalk in brown fat.