Dual-omics analysis of key biomarkers in T cell ubiquitination of rheumatoid arthritis blood and synovial tissue, validated by two-sample Mendelian randomization and qPCR - PubMed
5 hours ago
- #Mendelian randomization
- #T cell ubiquitination
- #rheumatoid arthritis
- Dual-omics analysis identified key biomarkers in T cell ubiquitination related to rheumatoid arthritis (RA).
- 521 blood-synovial ubiquitination-related genes (BS-UGs) and 21 T-cell-specific ubiquitination genes (BS-TUGs) were identified.
- Six key genes (DOCK10, DGKA, NOP58, JAK3, GCC2, ANO9) were selected using machine learning algorithms.
- NOP58 showed a positive causal association with RA, while GCC2 had a negative association.
- The study provides insights into immune regulation and potential therapeutic targets for RA.