Intratumoral Parvimonas micra promotes esophageal squamous cell carcinoma via p-cresol-induced Treg differentiation - PubMed
11 hours ago
- #microbiota
- #immunosuppression
- #ESCC
- Intratumoral microbiota influences cancer initiation and progression.
- Parvimonas micra (P. micra) is enriched in esophageal squamous cell carcinoma (ESCC) tumor tissues and linked to poor prognosis.
- P. micra abundance correlates with increased regulatory T cell (Treg cell) infiltration in the ESCC tumor microenvironment.
- P. micra promotes tumor growth by secreting p-cresol, a metabolite of amino acid fermentation.
- P-cresol elevates reactive oxygen species levels and induces FOXP3+ Treg differentiation, fostering immunosuppression and tumor growth.
- The study highlights the microbial contribution to ESCC progression and prognosis.