ACOD-itaconate in macrophage attenuates oxidative stress and inflammation in benign airway stenosis by upregulating and transferring FTH1 - PubMed
5 hours ago
- #inflammation
- #fibrosis
- #macrophage
- ACOD-itaconate in macrophages reduces oxidative stress and inflammation in benign airway stenosis (BAS).
- ACOD1 knockout worsens inflammation and increases granulation tissue formation.
- The ACOD1-itaconate axis, including 4-octyl itaconate (4-OI), mitigates fibrosis in BAS.
- 4-OI upregulates FTH1 in macrophages via NRF2 activation, suppressing oxidative stress and inflammation.
- 4-OI promotes FTH1 packaging into exosomes, transferred to fibroblasts via SCARA5, inducing ferroptosis and reducing fibrosis.
- The study highlights ACOD1-itaconate as a therapeutic target for fibrotic airway diseases.