The cTnI/cTnT Ratio in Myocardial Injury: A Multicohort and Experimental Synthesis - PubMed
6 hours ago
- #cardiac troponin
- #myocardial injury
- #diagnostic biomarker
- The study challenges the interchangeability of cardiac troponin I (cTnI) and T (cTnT) in clinical practice.
- The cTnI/cTnT ratio was found to differ significantly between acute necrotic and chronic/non-necrotic myocardial injury.
- A multicohort analysis involving 9,704 individuals showed the highest cTnI/cTnT ratio in acute cardiac disease (2.06), compared to chronic (0.66) and no known cardiac disease (0.50).
- Experimental models confirmed that mild nonlethal injury results in cTnT-dominant release, while lethal injury leads to cTnI-dominant release.
- Incorporating the cTnI/cTnT ratio improved discrimination between type 1 and type 2 acute myocardial infarction (AUC 0.73 vs 0.70).
- The findings suggest the cTnI/cTnT ratio has diagnostic value and challenges the current clinical interchangeability of cTnI and cTnT.