Risk of injury associated with the sedative potential of second-generation antihistamines: A nationwide retrospective cohort study - PubMed
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- #injury risk
- #sedation
- #antihistamines
- Study evaluates the risk of injury associated with the sedative potential of second-generation antihistamines during Japan's pollen season.
- Antihistamines were categorized into higher-sedation (≥10% central H1 occupancy) and lower-sedation (<10% central H1 occupancy) groups.
- No significant difference in injury risk was found between higher-sedation and lower-sedation antihistamine groups (2.6% vs. 2.6%).
- Subgroup analysis by age (<65 and ≥65 years) showed consistent results with no difference in injury risk.
- Conclusion: Sedative potential of second-generation antihistamines does not affect injury risk during pollen season in Japan.