Proteome-wide Mendelian randomisation identifies causal links between blood proteins and myopia - PubMed
a day ago
- #myopia
- #blood proteins
- #Mendelian randomisation
- Proteome-wide Mendelian randomisation identifies causal links between blood proteins and myopia.
- GWAS meta-analysis involving 43,862 myopia cases and 84,820 controls identified 26 genetic risk loci, including nine novel loci.
- Cross-sectional study of 50,586 individuals (3,108 with myopia) showed correlations between height, smoking, and myopia.
- Proteome-wide MR analysis identified 164 plasma proteins potentially causally linked to myopia, with 20 validated in both datasets.
- Genetic colocalisation, protein-protein interaction (PPI), and drug target analyses identified promising therapeutic targets for myopia.
- Findings offer new genetic insights into myopia and potential treatment targets for personalised therapeutic strategies.