Low dose radiation induces new protein synthesis that promotes cancer radiotherapy resistance - PubMed
5 hours ago
- #radiotherapy-resistance
- #proteasome-inhibitor
- #protein-synthesis
- Low-dose radiation (LDRT) promotes cancer radiotherapy resistance by triggering new protein synthesis.
- High-dose radiotherapy (HDRT) induces a strong DNA damage response (DDR) for resistance.
- LDRT enhances protein synthesis via mTOR signaling and 80S ribosome assembly.
- Proteasome inhibitor (PI) combined with LDRT leads to cancer cell death by accumulating DNA and protein damage.
- A chemoradiotherapy strategy combining LDRT and PI minimizes non-targeted toxicity.